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BSA is a more accurate measure of obesity, including central obesity, as it is a measurement of area and is able to account for the difference between muscle and fat better than BMI secondary to muscle versus fat. So the Mosteller formula was used in our study to calculate BSA. The detailed criteria of each group are shown in online supplementary table S1. In children, the high group included subjects with height or weight equal to or greater than the reference standard for each age group 1 year a group for the two genders. BMI was classified according to the reference calculated using the reference height and weight of each age group 1 year a group for the two genders.

Statistical analysis Comparison of height, weight and age between patients with and without thyroid nodules was conducted by t test. Listwise deletion was used to address the missing data in the model. The adjusted associations of height, weight, BMI and BSA with thyroid nodules were estimated using a logistic regression model stratified by gender. The variables showing a significant difference between the group with and without thyroid nodules were taken as covariates in logistic regression models: For adults, age was classified into five classes: For children, age was classified into four classes: To account for the correlation of members in the same household, we calculated robust estimates of variances with a generalised estimating equation using the SAS procedure GENMOD.

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